Backtracking a Case of Apples and Pears?
نویسندگان
چکیده
marrow material taken during therapy, it will be possible to explore if these second cancers emerge before the initiation of thiopurine therapy.4 Second, if de Boer et al are correct in their hypothesis, we would expect a reduced level of DNA-6TGN incorporation in the HGPRT-deficient t-AML/MDS clones compared with the normal bone marrow cells when such cases occur during thiopurine therapy. Using highly specific techniques for cell sorting6 and sensitive methods for quantification of DNA-6TGN,1 it will be feasible to explore if the t-AML/MDS cases that arise during thiopurine therapy contain lower DNA-6TGN levels than the remaining normal nucleated bone marrow cells.
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